|Figure 1. Green chemistry on water, monitored by the 5975-SMB GC-MS with Cold EI. Upper trace is a typical Cold EI mass chromatogram of the reaction mixture while the bottom trace is the Cold EI MS of product B.|
Conclusions and Discussion
We used the Aviv Analytical 5975-SMB GC-MS with Cold EI to enable semi-on-line, monitoring of reacting compounds and products mixtures, followed by a simple GC-FID that was operated as an unsupervised walk-by analytical instrument by the organic chemistry student for the quantification of the already known reaction products. A full description of the use of GC-MS with Cold EI for the optimization of chemical reactions with few examples can be found in A. Amirav, A. Gordin, Y. Hagooly, S. Rozen, B. Belgorodsky, B. Seemann, H. Marom, M. Gozin and A. B. Fialkov, "Measurement and Optimization of Organic Chemical Reaction Yields by GC-MS with Supersonic Molecular Beams" Tetrahedron 68, 5793-5799 (2012). The technology of GC-MS with Cold EI is reviewed by A. Amirav, A. Gordin, M. Poliak, and A. B. Fialkov, J. Mass Spectrom., 43, 141-163 (2008). The green chemistry reaction is further described in T. Sela and A. Vigalok, "Salt-Controlled Selectivity in on Water and In Water Passerini-Type Multi-component Reactions" Advanced Synthesis & Catalysis 354, 2407-2411 (2012).