GC-MS is characterized by many performance aspects and most of them are not mentioned or discussed by the GC-MS vendors and/or by any user's paper. The purpose of this paper is to list 72 such performance parameters and discuss how Cold EI improves the vast majority of them. GC-MS with Cold EI is based on a GC and MS interface with a Supersonic Molecular Beam (SMB) and on electron ionization of sample compounds while they are vibrationally cold in the SMB (thus named Cold EI) in a contact-free fly-through ion source.
Cold EI Improves all the central GC-MS performance aspects, including: identification, mass spectral information, range of compounds that are amenable for analysis, sensitivity (detection limits), speed of analysis, and response uniformity.
Cold EI Improves all the central GC-MS performance aspects, including: identification, mass spectral information, range of compounds that are amenable for analysis, sensitivity (detection limits), speed of analysis, and response uniformity.
Eight categories of GC-MS performances are listed below and in each of them we have several sub categories (given in the number in bracket):
- Improved sample identification (13).
- Extending the range of compounds amenable for GC-MS analysis (3).
- Speed – faster GC-MS analysis (9).
- Sensitivity (12).
- Uniform, compound independent ion source response, quantitation and reproducibility (4).
- Improved compatibility with GC-MS enhancement technologies (11).
- Improved GC-MS maintenance, flexibility, ease of use and price (15).
- Improved utilization of mass analyzer specifications (5).
Quoting Aristotle "The whole is greater than the sum of its parts", this combination of so many improvements (>60) creates a new and qualitatively superior technology that actually improves every type of analysis. While GC-MS with Cold EI enables new type of analyses and significantly improves challenging analyses, it does not impede on any simple method of analysis (compared with standard EI). Consequently, GC-MS with Cold EI is leading the way to the future of GC-MS.
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